Our newest preprint pub­li­ca­tion on the rela­tion­ship between obe­si­ty and work­ing mem­o­ry has under­gone rig­or­ous review by eLife, shed­ding new light on the inter­play between BMI and cog­ni­tive function. The study, led by researcher Nadine Her­zog, reveals com­pelling insights into how genet­ic vari­ants influ­enc­ing stri­atal dopamine sig­nal­ing impact the neg­a­tive...

Does obe­si­ty relate to impair­ments in work­ing mem­o­ry gat­ing? That is what the study by Nadine Her­zog et al. focused on, and the results sug­gest it’s not about BMI per se – a BMI-genet­ic inter­ac­tion might play a role. Read more about the intrigu­ing insights here.

Our lat­est paper is con­cerned with dopamine release, dif­fu­sion and uptake. We pro­vide a com­pu­ta­tion­al mod­el (and cor­re­spond­ing soft­ware) which helps to refine our under­stand­ing of dopamine trans­mis­sion, in par­tic­u­lar the effects of pre-synap­tic mech­a­nisms. We hope it will be used fur­ther to inves­ti­gate clin­i­cal ques­tions asso­ci­at­ed with dopamine dys­func­tion...